No. Misdirection's targeting requirement is a target "spell with a single target". Since Kolaghan's Command will always have 2 targets, you can't cast Misdirection targeting it.
Rule 114.8a: An object that looks for a “[spell or ability] with a single target” checks the number of times any objects, players, or zones became the target of that spell or ability when it was put on the stack, not the number of its targets that are currently legal. If the same object, player, or zone became a target more than once, each of those instances is counted separately.
Kolaghan's Command
If an opponent targets me with two modes of K Command Can I use Misdirection to change the target?
RULES OF MAGIC :
http://magic.wizards.com/en/game-info/gameplay/rules-and-formats/rules