Vigilance becomes very good in multiplayer, so decent cards like Elite Inquisitor, Serra Avenger, and Loyal Cathar become quite good. It might even be worth it to consider Serra Angel, depending on if your playgroup would use her in 1v1.
Some cards that are pretty good in multiplayer but probably wouldn't cut it in 1v1 are Pestilence, it's red cousin Pyrohemia and super multiplayer fatty Hydra Omnivore. Probably depends on the general power level of your cube though.
Vigilance becomes very good in multiplayer, so decent cards like Elite Inquisitor, Serra Avenger, and Loyal Cathar become quite good. It might even be worth it to consider Serra Angel, depending on if your playgroup would use her in 1v1.
Some cards that are pretty good in multiplayer but probably wouldn't cut it in 1v1 are Pestilence, it's red cousin Pyrohemia and super multiplayer fatty Hydra Omnivore. Probably depends on the general power level of your cube though.